资源类型

期刊论文 97

年份

2023 6

2022 14

2021 6

2020 6

2019 6

2018 12

2017 5

2016 2

2015 6

2014 4

2013 2

2012 1

2010 5

2009 3

2008 4

2007 2

2006 2

2005 1

2003 1

2000 1

展开 ︾

关键词

免疫调节 2

炎症 2

疫苗 2

3D打印 1

5型腺病毒 1

COVID-19 1

CyTOF 1

SARS-CoV-2 1

Walsh循环谱 1

三维布局；势能曲面变平；布局优化；性能约束 1

严格雪崩准则 1

中药 1

临床特征 1

主动回收 1

乙型肝炎 1

人体经络 1

人工势场 1

什刹前海 1

体液免疫应答 1

展开 ︾

检索范围：

排序： 展示方式：

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

《医学前沿（英文）》 2021年 第15卷 第1期   页码 33-42 doi: 10.1007/s11684-019-0735-3

摘要： Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitors (ICIs) are the most successful agents approved for multiple advanced malignancies. However, given the nature of the non-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related adverse events (irAEs) in almost all organs or systems. Up to 90% of patients who received ICIs combination therapy experienced irAEs, of which majority were low-grade toxicity. Cytotoxic lymphocyte antigen-4 and programmed cell death protein-1/programmed cell death ligand 1 inhibitors usually display distinct features of irAEs. In this review, the mechanisms of action of ICIs and how they may cause irAEs are described. Some unsolved challenges, however really engrossing issues, such as the association between irAEs and cancer treatment response, tumor response to irAEs therapy, and ICIs in challenging populations, are comprehensively summarized.

关键词： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

HTML PDF 收藏

The ecological system and the regionalization of landscape reconstruction in northwest of China

Peicheng LI,Guoyuan DU,Qilei LI,Jinfeng WANG,Feimin ZHENG

《农业科学与工程前沿（英文）》 2014年 第1卷 第4期   页码 291-298 doi: 10.15302/J-FASE-2014033

摘要： The northwest of China is a vast area with abundant resources and significant potential for development. However, the ecological system is extremely vulnerable to damage and must be managed carefully. Thus, the Chinese government is strengthening research on improvement and reconstruction of the ecological system and landscape in northwest of China while moving forward with large-scale development in west China. The disadvantages and vulnerabilities in the northwest area in China are presented. It is suggested that the reconstruction of landscape should be conducted by step by step regionalization across the various ecological systems in the 3.04 million km northwest area of China. The first level regionalization results of reconstruction of landscape are discussed.

关键词： reconstruction of landscape     ecological system     the northwest area of China     science and technology action    

HTML PDF 收藏

Research on a quantificational method for chromatic-light emotions of architectural wall coatings in landscape

Ting WANG, Ma JIAN, Gang LIU, Xiaoxi LIU, Mingyu ZHANG

《结构与土木工程前沿（英文）》 2010年 第4卷 第4期   页码 498-502 doi: 10.1007/s11709-010-0096-0

摘要： Research on quantificational methods for chromatic-light emotion is an effective way of finding out the laws of light cognitive impact and the solution to the problem on application of light color in landscape lighting. This paper took chromatic-light-induced-emotion towards architectural wall coatings in landscape as the research object. The methods in use were real-state simulation and laboratory quantitative study. Consequently, the study successfully extracted light emotional factors and the rule of predictability to assist landscape light professionals.

关键词： landscape illumination     architectural wall coatings     chromatic-light emotion     quantitative research    

HTML PDF 收藏

Natural killer cells in liver diseases

null

《医学前沿（英文）》 2018年 第12卷 第3期   页码 269-279 doi: 10.1007/s11684-018-0621-4

摘要：

The liver has been characterized as a frontline lymphoid organ with complex immunological features such as liver immunity and liver tolerance. Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infection, autoimmune disease, and tumors. The liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypic and functional characteristics. NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infected cells, depends on the balance between numerous activating and inhibitory signals. In addition to the innate direct “killer” functions, NK cell activity contributes to regulate innate and adaptive immunity (helper or regulator). Under the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune responses, leading to either immune activation or immune tolerance. Here, we focus on the relationship between NK cell biology, such as their phenotypic features and functional diversity, and liver diseases.

关键词： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

HTML PDF 收藏

FLOWERING PLANTS AND ENTOMOPHAGOUS ARTHROPODS IN THE AGRICULTURAL LANDSCAPE: A PRACTISE-ORIENTED SUMMARY

《农业科学与工程前沿（英文）》 2022年 第9卷 第1期   页码 63-74 doi: 10.15302/J-FASE-2021427

摘要：

There is a growing demand for high-quality agricultural products and more countries have adopted landscape management by sowing flowering plants in agricultural fields as an important branch of conservation biological control. However, there has been less concern over the interactions and trade-offs between floral plants and entomophagous arthropods. This paper review progress in pollen/nectar feeding habits of entomophagous insects including parasitoids and predators which are important natural enemies of crop pests in agricultural fields. Factors that influence the preference of different guilds of natural enemies are reviewed to guide the selection of flowering plants in conservation biological control practices. Most studies find that floral resources have positive effects on both biological traits of natural enemies and their abundance and diversity, and this is believed to contribute greatly to pest control. Furthermore, the potential impacts of floral resources on crop yields are also discussed with an emphasis on a guild of entomophagous insects that provides both pest control and pollination services.

 

关键词： ecosystem services / flowering plants / natural enemies / nectar / pollen    

HTML PDF 收藏

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

《医学前沿（英文）》 2020年 第14卷 第6期   页码 816-819 doi: 10.1007/s11684-020-0823-4

HTML PDF 收藏

of texture and irrigation on the soil moisture vertical-temporal variability in an urban artificial landscape

Xiaofeng ZHANG,Xu ZHANG,Guanghe LI

《环境科学与工程前沿（英文）》 2015年 第9卷 第2期   页码 269-278 doi: 10.1007/s11783-014-0672-y

摘要： Soil moisture variability in natural landscapes has been widely studied; however, less attention has been paid to its variability in the urban landscapes with respect to the possible influence of texture stratification and irrigation management. Therefore, a case study was carried out in the Beijing Olympic Forest Park to continuously monitor the soil in three typical profiles from 26 April to 11 November 2010. The texture stratification significantly affected the vertical distribution of moisture in the non-irrigated profile where moisture was mostly below field capacity. In the profile where irrigation was sufficient to maintain moisture above field capacity, gravity flow led to increased moisture with depth and thus eliminated the influence of texture. In the non-irrigated sites, the upper layer (above 80 cm) exhibited long-term moisture persistence with the time scale approximating the average rainfall interval. However, a coarse-textured layer weakened the influence of rainfall, and a fine-textured layer weakened the influence of evapotranspiration, both of which resulted in random noise-like moisture series in the deeper layers. At the irrigated site, frequent irrigation neutralized the influence of evapotranspiration in the upper layer (above 60 cm) and overshadowed the influence of rainfall in the deeper layer. As a result, the moisture level in the upper layer also behaved as a random noise-like series; whereas due to deep transpiration, the moisture of the deep layer had a persistence time-scale longer than a month, consistent with characteristic time-scales found for deep transpiration.

关键词： moisture vertical distribution     moisture temporal variation     texture stratification     irrigation     meteorological forcing     urban landscape    

HTML PDF 收藏

Heterogeneity of the tumor immune microenvironment and clinical interventions

《医学前沿（英文）》 2023年 第17卷 第4期   页码 617-648 doi: 10.1007/s11684-023-1015-9

摘要： Heterogeneity of the tumor immune microenvironment and clinical interventions

关键词： Heterogeneity tumor immune    

HTML PDF 收藏

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 229-235 doi: 10.1007/s11684-017-0581-0

摘要：

On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.

关键词： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

HTML PDF 收藏

nitrogen/phosphorus concentration and hydraulic retention time for bloom control in reclaimed water landscape

《环境科学与工程前沿（英文）》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1564-1

摘要：

● A new model for bloom control in open land scape water was constructed.

关键词： Reclaimed water landscape     Algal bloom     Nitrogen and phosphorus     Hydraulic retention time     Threshold     Control model    

HTML PDF 收藏

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

《医学前沿（英文）》   页码 889-906 doi: 10.1007/s11684-023-0994-x

摘要： Primary central nervous system lymphoma (PCNSL) is an uncommon non-Hodgkin’s lymphoma with poor prognosis. This study aimed to depict the genetic landscape of Chinese PCNSLs. Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristics and clinicopathologic features were also analyzed. Structural variations were identified in all patients with a mean of 349, which did not significantly influence prognosis. Copy loss occurred in all samples, while gains were detected in 77.9% of the samples. The high level of copy number variations was significantly associated with poor progression-free survival (PFS) and overall survival (OS). A total of 263 genes mutated in coding regions were identified, including 6 newly discovered genes (ROBO2, KMT2C, CXCR4, MYOM2, BCLAF1, and NRXN3) detected in ≥ 10% of the cases. CD79B mutation was significantly associated with lower PFS, TMSB4X mutation and high expression of TMSB4X protein was associated with lower OS. A prognostic risk scoring system was also established for PCNSL, which included Karnofsky performance status and six mutated genes (BRD4, EBF1, BTG1, CCND3, STAG2, and TMSB4X). Collectively, this study comprehensively reveals the genomic landscape of newly diagnosed Chinese PCNSLs, thereby enriching the present understanding of the genetic mechanisms of PCNSL.

关键词： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation     gene mutation    

HTML PDF 收藏

Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

null

《医学前沿（英文）》 2014年 第8卷 第1期   页码 1-5 doi: 10.1007/s11684-014-0309-3

摘要：

Hyperthermia is a condition characterized by increased body temperature as a consequence of failed thermoregulation. Hyperthermia occurs when a body produces or absorbs more heat than it dissipates. Hyperthermia also elicits various effects on the physiology of living cells. For instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immune cells, including antigen-presenting cells, T cells, and natural killer cells. Heat shock temperature (41β°C to 43β°C) can increase the immunogenicity of tumor cells. Cytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune response. The immunomodulatory effect of hyperthermia has promoted an interest in hyperthermia-aided immunotherapy, particularly against tumors. Hyperthermia has also been used to treat deep fungal, bacterial, and viral skin infections. We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing local hyperthermia. More than half of the patients were significantly cured compared with those in the control trial. A series of challenging clinical cases, such as large lesions in pregnant patients or patients with diabetes mellitus, were also successfully and safely managed using the proposed method. However, further studies should be conducted to clarify the underlying mechanisms and promote the clinical applications of hyperthermia.

关键词： hyperthermia     HPV     immune response     virus     tumor    

HTML PDF 收藏

SARS-CoV-2 variants, immune escape, and countermeasures

《医学前沿（英文）》 2022年 第16卷 第2期   页码 196-207 doi: 10.1007/s11684-021-0906-x

摘要： Coronavirus disease 2019 (COVID-19) has become a global pandemic disease. SARS-CoV-2 variants have aroused great concern and are expected to continue spreading. Although many countries have promoted roll-out vaccination, the immune barrier has not yet been fully established, indicating that populations remain susceptible to infection. In this review, we summarize the literature on variants of concern and focus on the changes in their transmissibility, pathogenicity, and resistance to the immunity constructed by current vaccines. Furthermore, we analyzed relationships between variants and breakthrough infections, as well as the paradigm of new variants in countries with high vaccination rates. Terminating transmission, continuing to strengthen variant surveillance, and combining nonpharmaceutical intervention measures and vaccines are necessary to control these variants.

关键词： SARS-CoV-2     COVID-19     vaccine     immune escape     breakthrough     prevention    

HTML PDF 收藏

Multi-target combinatory strategy to overcome tumor immune escape

《医学前沿（英文）》 2022年 第16卷 第2期   页码 208-215 doi: 10.1007/s11684-022-0922-5

摘要： Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancer treatment. Many immune checkpoints were identified in the last decade since ipilimumab, which is the first immune checkpoint inhibitor to cytotoxic T-lymphocyte associated protein 4, had been approved by the US Food and Drug Administration (FDA) for the treatment of unresectable or metastatic melanoma in 2011. The use of several antibody drugs that target PD1/PD-L1 for various cancer treatments has been approved by the FDA. However, fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers. Approximately 80% of patients do not respond appropriately because of primary or acquired therapeutic resistance. Along with the characterization of more immune checkpoints, the combinatory treatment of multi-immune checkpoint inhibitors becomes a new option when monotherapy could not receive a good response. In this work, the author focuses on the combination therapy of multiple immune checkpoints (does not include targeted therapy of oncogenes or chemotherapy), introduces the current progression of multiple immune checkpoints and their related inhibitors, and discusses the advantages of combination therapy, as well as the risk of immune-related adverse events.

关键词： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

HTML PDF 收藏

以东为鉴 秀丽晚成——西部风景园林开发浅议

孟兆祯

《中国工程科学》 2000年 第2卷 第10期   页码 56-58

摘要：

首先我们要站在人类社会生产与自然环境协调的可持续发展的高度着手综合的国土规划，建立从总体到单体的规划设计科学序列。现阶段城市的本质应为人类聚居并藉以生存的生活环境。城市化进程与自然环境间并非针锋相对的破坏关系。城市形象不仅仅是建筑加道路的形象，而是以人工美入自然，将城市和建筑融汇到自然环境中的形象。我们美好的前景是将城市和建筑建在绿色环境中。风景名胜区和城市园林的建设当前仍须将保护自然资源放在首位。要创造特色，从各市的自然环境和人文脉络中捕捉城市风景园林的特色，不要盲目跟风。秀丽山川，大器晚成。扎实积累，功到必成。

关键词： 城市化进程     风景名胜区     城市园林    

HTML PDF 收藏

标题 作者 时间 类型 操作

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

期刊论文

The ecological system and the regionalization of landscape reconstruction in northwest of China

Peicheng LI,Guoyuan DU,Qilei LI,Jinfeng WANG,Feimin ZHENG

期刊论文

Research on a quantificational method for chromatic-light emotions of architectural wall coatings in landscape

Ting WANG, Ma JIAN, Gang LIU, Xiaoxi LIU, Mingyu ZHANG

期刊论文

Natural killer cells in liver diseases

null

期刊论文

FLOWERING PLANTS AND ENTOMOPHAGOUS ARTHROPODS IN THE AGRICULTURAL LANDSCAPE: A PRACTISE-ORIENTED SUMMARY

期刊论文

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

期刊论文

of texture and irrigation on the soil moisture vertical-temporal variability in an urban artificial landscape

Xiaofeng ZHANG,Xu ZHANG,Guanghe LI

期刊论文

Heterogeneity of the tumor immune microenvironment and clinical interventions

期刊论文

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

null

期刊论文

nitrogen/phosphorus concentration and hydraulic retention time for bloom control in reclaimed water landscape

期刊论文

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

期刊论文

Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

null

期刊论文

SARS-CoV-2 variants, immune escape, and countermeasures

期刊论文

Multi-target combinatory strategy to overcome tumor immune escape

期刊论文

以东为鉴 秀丽晚成——西部风景园林开发浅议

孟兆祯

期刊论文